Cannabis and How It May Help to Prevent Acute Respiratory Distress Syndrome (ARDS) - Anamika Mehta, Molecular Genetic Scientist

ARDS is what is leading to so may deaths by Covid19 as we yet do not have cure for it.

Cannabis once it enters body, cannabinoids (bioactive component) binds to the CB1 receptors in your brain, leading to influencing the brain, such as reducing anxiety. CB2 receptors are found mostly in our immune system and peripheral nervous system. Like pharmaceuticals, cannabis targets CB1 and CB2, hence, cannabis works as medicine. Cannabis has been shown to have fewer negative side effects than typical pharmaceuticals. Cannabis also has an extreme “lack of toxicity,” meaning you cannot take a lethal dose of cannabis. Our bodies respond positively to cannabis it’s just the start of understanding, how it works. Various locks in the body are unlocked by cannabis.

Example, how it works on cytokines.

First, what are cytokines?

These are small proteins that mediate & regulate immune system and inflammation. Also involved in the formation and development of blood cells. Soluble protein or glycoprotein molecules secreted by a variety of cells in response to a foreign antigen or other stimulus.

 

 

Cytokines act as intercellular messengers because a cytokine secreted by one cell act on another cell and influences its functions- signalling protein.

It regulates local and systemic immune and inflammatory responses as well as wound healing and many other biologic activities.

 

There are various types of receptors on cytokines. Type I cytokine receptors, whose members have certain conserved motifs in their extracellular amino-acid domain and Type II cytokine receptors, mainly have interferons.

Immunoglobulin (Ig) superfamily, which are ubiquitously present throughout several cells and tissues of the vertebrate body

Cannabis decreases the production of pro-inflammatory cytokines. Hence, helps prevent inflammation. CBD has shown to reduce pro-inflammatory signals (i.e. cytokines) via CB2 receptor signalling mechanisms.  Essentially innate immunity function improves with cannabis-mediated signalling, thus cleaning up the inflammation in the local tissue sites harbouring infection.

Anamika Mehta, Molecular Genetic Scientist

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